Transient Receptor Potential Vanilloid 1 Antagonist, Capsazepine, Improves Survival in a Rat Hemorrhagic Shock Model
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چکیده
منابع مشابه
Capsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis
Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...
متن کاملcapsazepine, a transient receptor potential vanilloid type 1 (trpv1) antagonist, attenuates antinociceptive effect of cb1 receptor agonist, win55,212-2, in the rat nucleus cuneiformis
introduction: nucleus cuneiformis (ncf), as part of descending pain inhibitory system, cooperates with periaqueductal gray (pag) and rostral ventromedial medulla (rvm) in supraspinal modulation of pain. cannabinoids have analgesic effects in the pag, rvm and ncf. the transient receptor potential vanilloid type 1(trpv1) can be activated by anandamide and win55,212-2 as a cannabinoid receptor ago...
متن کاملEffects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.
BACKGROUND Repeated morphine treatment has been shown to induce transient receptor potential vanilloid type 1 (TRPV1) expression in the spinal cord, dorsal root ganglion (DRG), and sciatic nerve of a rat model. Increased TRPV1 expression may therefore play a role in morphine tolerance. In this study, we evaluated the hypothesis that blockage of TRPV1 may be useful as an adjunctive pain manageme...
متن کاملTransient Receptor Potential Vanilloid 1
Background and structure Transient receptor potential vanilloid receptor 1 (TRPV1) is one of 6 members of the subfamily of vanilloid receptors that belongs to the family of transient receptor potential (TRP) channels. TRP channels are an intrinsic part of the mammalian sensory system responding to a broad range of stimuli such as temperature, touch, pain, osmolarity, pheromones, and taste (8). ...
متن کاملCapsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis
* Corresponding Author: Abbas Haghparast, Msc, PhD Associate Professor of Neurophysiology, Single Unit Recording Laboratory, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Evin St., Shahid Chamran Exp.way. P.O.Box: 19615-1178, Tehran, IRAN Tel/Fax: +98 21 2243 1624. Mobile: +98 912 214 9857 E-mail: Dr. [email protected]. Website: http://www.nrciran.com/ Introdu...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2007
ISSN: 0003-4932
DOI: 10.1097/01.sla.0000255577.80800.e1